Tumour Treating Fields (TTF)

Q1: What are Tumor Treating Fields (TTF)?
A: Tumor Treating Fields (TTF) are a non-invasive cancer treatment that uses electric fields to disrupt the division and growth of cancer cells. This therapy is delivered through a device that generates low-intensity, alternating electric fields, which interfere with cancer cell division, slowing down or stopping the tumor’s growth.

Q2: How do Tumor Treating Fields work?
A: TTF works by targeting rapidly dividing cancer cells. When cells divide, they undergo structural changes, making them vulnerable to electric fields. The TTF device generates alternating electric fields, which disrupt the alignment of molecules within the cancer cells, preventing them from dividing and proliferating. This ultimately slows the growth of the tumor and can lead to cancer cell death.

Q3: What types of cancer can be treated with Tumor Treating Fields?
A: Tumor Treating Fields are primarily used to treat:

• Glioblastoma (GBM): An aggressive form of brain cancer. TTF is often used in combination with chemotherapy after initial surgery and radiation.
• Mesothelioma: A rare cancer that affects the lining of the lungs. TTF can be used in combination with chemotherapy to improve treatment outcomes.

Research is ongoing to explore the use of TTF in other types of cancer, such as non-small cell lung cancer (NSCLC) and pancreatic cancer.

Q4: What are the benefits of Tumor Treating Fields?
A: The benefits of TTF include:

• Non-invasive treatment: TTF is a non-surgical, non-drug treatment that patients can use at home, allowing them to maintain their daily activities.
• Targeted therapy: TTF specifically targets cancer cells without affecting healthy cells, reducing the risk of side effects commonly associated with other treatments like chemotherapy and radiation.
• Combination with other treatments: TTF is often used alongside other therapies, such as chemotherapy, to enhance the overall effectiveness of cancer treatment.
• Improved survival: Clinical studies have shown that TTF can extend survival in patients with glioblastoma when used in conjunction with other treatments.

Q5: How is Tumor Treating Fields therapy administered?
A: TTF therapy is administered using a portable device that patients wear continuously. The device consists of electrodes (called transducer arrays) that are placed on the skin around the tumor site. These electrodes deliver the alternating electric fields to the tumor. The device is typically worn for at least 18 hours a day, and patients can carry out their daily activities while wearing it. The treatment is continuous, and regular follow-ups with the healthcare team are required to monitor progress and make adjustments.

Q6: Are there any side effects associated with Tumor Treating Fields?
A: TTF is generally well-tolerated, but there are some potential side effects, including:

• Skin irritation: The most common side effect is skin irritation or rash at the site where the electrodes are placed. This can usually be managed with topical treatments and regular care.
• Mild discomfort: Some patients may experience a sensation of warmth or mild discomfort from wearing the device.
• Fatigue: Like many cancer treatments, TTF can cause fatigue, especially when combined with other therapies.

Your healthcare team will provide instructions on how to care for your skin and manage any side effects.

Q7: How do I know if Tumor Treating Fields is the right treatment for me?
A: Whether TTF is suitable for you depends on several factors, including the type and stage of your cancer, your overall health, and your treatment goals. TTF is often recommended for patients with glioblastoma or mesothelioma, particularly when combined with other treatments like chemotherapy. Your oncologist will evaluate your specific situation and discuss whether TTF is a good option for you.

Q8: What should I expect while using Tumor Treating Fields?
A: While using TTF, you will need to wear the device most of the day, which may require some adjustments to your routine. Your healthcare team will guide you on how to apply and maintain the electrodes, as well as how to manage the device. Regular follow-ups are important to monitor your response to treatment and make any necessary adjustments. Many patients find that they can continue with their daily activities, including work and exercise, while using TTF.

If you have more questions about Tumor Treating Fields or are considering it as a treatment option, talk to your healthcare provider. They can provide detailed information and help you understand how TTF might fit into your overall cancer treatment plan